1. Irregular Periods? If your periods are irregular or even completely nonexistent, this could be a side effect of PCOS. Even if your cycles have never been regular, it’s worth getting checked, as many women have this condition for years and don’t even know it.

2. Acne? While acne itself isn’t a sure sign of PCOS, consider that this condition affects women of childbearing age. If you’ve developed acne or been dealing with it into adulthood, the cause could be a PCOS-related hormone imbalance. This is especially true if you’ve experienced one or more of the other symptoms on this list.

3. Weight Gain of difficulty losing weight? It’s normal to gain a couple pounds during celebratory times of the year, but if you’ve gained a lot of weight for seemingly no reason, it could be a red flag. Insulin resistance, a side effect of PCOS, (and according to most studies a major cause of PCOS) makes it easy to put on pounds and very difficult to lose them.

4. Excess hair in places that men normally have heair? Most women have to tweeze a little here and there, and many regularly remove fuzz from their upper lip. But if the hair or back, armpits, or on your face is growing in thick and sprouting in other places on your body, it could be from high levels of male hormones (androgens) which is a sign of PCOS.

5. Thinning hair or hair loss? Frustratingly, while excess hair can grow where you don’t want it, the hair on your head can start to thin or fall out. This, too, can be the result of excess “male” hormones known as androgens.

6. Infertility? PCOS affects hormones, largely due to insulin resistance, which impacts ovulation. Often, women don’t discover they have this condition until they start having trouble conceiving. In fact, PCOS is the leading cause of infertility worldwide.